______ his knowledge of the mountainous country, John Smith was appointed as our guide.
A. In spite of B. On account of 
Regardless of D. Instead of
What really ______ is not failure itself, but the attitude we have towards it.
| A．matters | B．applies | C．stresses | D．functions |
I have been told that the new law will come into ______ on January 1st next year.
| A．effect | B．use | C．service | D．existence |
Our company is seeking for a manager, especially ______ with creativity and imagination.
| A．the one | B．each | C．one | D．that |
The boy was so careless that the glass fell from his hand and it ______ on the floor.
| A．broke in | B．broke down | C．broke up | D．broke out |
Shall we take ______ short break? I want to make ______ call.
| A．the; a | B．a; the | C．the; the | D．a; a |